Three-tissue compositional analysis reveals in-vivo microstructural heterogeneity of white matter hyperintensities following stroke

W Khan; N Egorova; MS Khlif; R Mito; T Dhollander; A Brodtmann

Journal article

Three-tissue compositional analysis reveals in-vivo microstructural heterogeneity of white matter hyperintensities following stroke

W Khan, N Egorova, MS Khlif, R Mito, T Dhollander, A Brodtmann

Neuroimage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020

DOI: 10.1016/j.neuroimage.2020.116869

Abstract

White matter hyperintensities (WMHs) are frequently observed on brain scans of older individuals and are associated with cognitive impairment and vascular brain burden. Recent studies have shown that WMHs may only represent an extreme end of a diffuse pathological spectrum of white matter (WM) degeneration. The present study investigated the microstructural characteristics of WMHs using an advanced diffusion MRI modelling approach known as Single-Shell 3-Tissue Constrained Spherical Deconvolution (SS3T-CSD), which provides information on different tissue compartments within each voxel. The SS3T-CSD method may provide complementary information in the interpretation of pathological tissue thro..

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University of Melbourne Researchers

Natalia Egorova-Brumley Author

Remika Mito Author

Amy Brodtmann Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work is supported by the National Health and Medical Research Council (NHMRC) Dementia Research Team Grant (APP1094974) at the Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.